Journal article
Persistent Impairment in Cardiopulmonary Fitness after Breast Cancer Chemotherapy
SJ Foulkes, EJ Howden, A Bigaran, K Janssens, Y Antill, S Loi, P Claus, MJ Haykowsky, RM Daly, SF Fraser, A La Gerche
Medicine and Science in Sports and Exercise | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Abstract
Purpose Anthracycline chemotherapy (AC) is associated with acute reductions in cardiopulmonary fitness (VO2peak). We sought to determine whether changes in VO2peak and cardiac function persisted at 12 months post-AC completion, and whether changes in cardiac function explain the heightened long-term heart failure risk. Methods Women with breast cancer scheduled for AC (n = 28) who participated in a nonrandomized trial of exercise training (ET; n = 14) or usual care (UC; n = 14) during AC completed a follow-up evaluation 12 months post-AC completion (16 months from baseline). At baseline, 4 months, and 16 months, participants underwent a resting echocardiogram (left ventricular ejection fract..
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Awarded by Jack Brockhoff Foundation
Funding Acknowledgements
This project was supported by a project grant from the Jack Brockhoff Foundation, Australia (JBF 4039). Andre La Gerche is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC 1089039) and a Future Leaders Fellowship from the National Heart Foundation (NHF 100409) of Australia. Stephen Foulkes is supported by an Australian Government Research Training Program Scholarship (RTP 4635089552). Professor Haykowsky is funded, in part, by the Moritz Chair in Geriatrics in the College of Nursing and Health Innovation at the University of Texas at Arlington.